

| Dosage | Package | Price per Dose | Price | |
|---|---|---|---|---|
| 25mg | 360 pill | β¬0.67 | β¬302.76 β¬242.21 Best Price | |
| 25mg | 270 pill | β¬0.69 | β¬232.89 β¬186.31 | |
| 25mg | 180 pill | β¬0.73 | β¬164.81 β¬131.85 | |
| 25mg | 120 pill | β¬0.82 | β¬121.81 β¬97.45 | |
| 25mg | 90 pill | β¬0.89 | β¬100.31 β¬80.25 | |
| 25mg | 60 pill | β¬0.97 | β¬73.44 β¬58.75 | |
| 25mg | 30 pill | β¬1.05 | β¬39.40 β¬31.52 | |
| 50mg | 360 pill | β¬0.90 | β¬406.67 β¬325.34 | |
| 50mg | 270 pill | β¬0.95 | β¬318.89 β¬255.11 | |
| 50mg | 180 pill | β¬0.99 | β¬222.14 β¬177.71 | |
| 50mg | 120 pill | β¬1.09 | β¬163.02 β¬130.41 | |
| 50mg | 90 pill | β¬1.18 | β¬132.56 β¬106.05 | |
| 50mg | 60 pill | β¬1.32 | β¬98.52 β¬78.82 | |
| 50mg | 30 pill | β¬1.43 | β¬53.73 β¬42.98 | |
| 100mg | 360 pill | β¬1.33 | β¬600.17 β¬480.13 Popular | |
| 100mg | 270 pill | β¬1.43 | β¬483.71 β¬386.97 | |
| 100mg | 180 pill | β¬1.50 | β¬338.59 β¬270.87 | |
| 100mg | 120 pill | β¬1.65 | β¬247.22 β¬197.78 | |
| 100mg | 90 pill | β¬1.75 | β¬197.06 β¬157.65 | |
| 100mg | 60 pill | β¬1.82 | β¬136.14 β¬108.91 | |
| 100mg | 30 pill | β¬2.05 | β¬77.02 β¬61.62 |
This information is for guidance only and does not replace medical advice. For personalised advice, please consult your doctor or pharmacist.
Zoloft is the brand name for a medicine called sertraline. It belongs to a class of drugs known as selective serotonin reuptake inhibitors (SSRIs).
Sertraline works by increasing the level of serotonin, a chemical in the brain that helps regulate mood, emotions and certain thoughts. This change in brain chemistry can help improve mood and reduce anxiety in some people.
The medicine is taken by mouth, usually as tablets or dispersible tablets that dissolve in water. It should be taken exactly as prescribed by your doctor. Do not adjust the dose or stop taking it without professional advice, as stopping suddenly can cause withdrawal symptoms.
In Ireland and many other places, medicines like Zoloft may require a prescription depending on local rules. Your pharmacist can explain how the medicine is supplied and how to take it correctly. If you have any questions about how this medicine fits with your health needs, ask your pharmacist or doctor.
Zoloft is used to help manage a range of mental health conditions. It is generally prescribed as part of a broader treatment approach that can include talking therapies and lifestyle changes.
Common conditions that may be treated with sertraline include the following. Your clinician will decide if this medicine is appropriate for you, and the exact dose and duration will depend on your situation.
Sertraline may be used for other conditions as judged appropriate by a clinician. If you are unsure why you have been prescribed this medicine, check the patient information leaflet or speak with your doctor or pharmacist. Do not use it for conditions other than those advised by a healthcare professional.
Sertraline increases the amount of serotonin available in parts of the brain that regulate mood, which can help improve symptoms over time. It does not provide immediate relief, and the effects may develop gradually with ongoing treatment.
The exact way sertraline helps with different conditions can vary. For most people, it may take several weeks before mood or anxiety improves. In some cases, the full benefit may take longer, and ongoing treatment is often needed to maintain improvement.
Like other antidepressants, sertraline is part of a broader treatment plan. Psychotherapy, lifestyle changes, and regular follow-up with a clinician are important parts of achieving and maintaining benefit. If you have questions about how this medicine fits with your overall treatment, discuss them with your doctor or pharmacist.
If you notice a change in your symptoms or mood that worries you after starting sertraline, contact your clinician for advice. Do not adjust your treatment on your own based on temporary changes in how you feel.
Take Zoloft exactly as prescribed by your doctor. The medicine is usually taken once daily. Your doctor will tell you the best time to take it, which may be in the morning or in the evening depending on how it affects you.
Swallow the tablets whole with a drink of water. If you have trouble swallowing, your pharmacist can explain the dispersible form and how to dissolve it properly in water before drinking.
You can take Zoloft with or without food. Do not crush, chew, or break tablets unless you are given specific instructions for a dispersed form. If you have any difficulty taking the medicine, talk to your pharmacist about available options.
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your regular schedule. Do not take two doses at the same time to make up for a forgotten dose. If you have missed doses for several days, contact your clinician for advice before resuming treatment.
Sertraline is not suitable for everyone. A clinician will assess your medical history and current medicines to decide if Zoloft is appropriate for you.
You should not take Zoloft if you have a known allergy to sertraline or any of the other ingredients in the medicine. An allergic reaction can be serious and requires urgent medical attention.
Avoid Zoloft if you are taking, or have recently taken, monoamine oxidase inhibitors (MAO inhibitors) or certain other medicines used to treat mood disorders. The timing of starting and stopping these medicines is important to avoid dangerous interactions. Always tell your doctor about all medicines you use, including over-the-counter products and supplements.
In addition, people with a history of bipolar disorder, mania, severe liver or kidney disease, seizures that are not well controlled, or certain heart conditions may need careful monitoring or an alternative treatment. A discussion with your doctor will help determine the best option for you. If you are pregnant, planning a pregnancy, or breastfeeding, talk to your clinician about risks and benefits before starting or continuing treatment.
Sertraline can have serious interactions and side effects in some people. It is important to monitor mood, behaviour, and physical symptoms, especially at the start of treatment or when changing the dose.
One important safety consideration is the possibility of increased suicidal thoughts or new mood changes in some people, particularly young adults during the first weeks of treatment. Seek immediate help from a healthcare professional if you notice new or worsening thoughts of self-harm, or any sudden changes in mood or behaviour.
Sertraline can interact with other medicines and substances that affect serotonin or blood clotting. These interactions can cause conditions such as serotonin syndrome or unusual bleeding. Always discuss all medicines you take with your doctor and pharmacist before starting Zoloft, and report any new medications you begin during treatment.
Other warnings include the potential for low sodium levels (hyponatremia), especially in older adults, and the possibility of withdrawal symptoms if the medicine is stopped abruptly. If you need to stop treatment, your clinician will guide you on a safe tapering plan to minimise withdrawal effects.
Most people tolerate Zoloft well, especially after the first few weeks. However, side effects can occur, especially when starting treatment or adjusting the dose. Some may fade with time as the body adjusts.
Common side effects include mild stomach upset, nausea, diarrhoea, dry mouth, headaches, sleep disturbances (including trouble sleeping or sleepiness), dizziness, increased sweating, or changes in appetite or weight. Sexual side effects such as reduced sexual desire or difficulty achieving an orgasm may also occur for some people.
If side effects are bothersome or persistent, speak with your doctor or pharmacist. They can advise on strategies to manage symptoms or discuss whether a dose adjustment is appropriate. Do not stop taking Zoloft suddenly without medical advice, as this can cause withdrawal symptoms.
Serious but less common side effects that require urgent medical attention include signs of an allergic reaction (rash, swelling, trouble breathing), severe skin reactions, signs of serotonin syndrome (confusion, fever, agitation, tremor, rapid heartbeat, muscle stiffness), severe mood changes, or unusual bleeding. If you notice any of these, seek medical help promptly and inform your clinician about your medicine use.
Many medicines and substances can interact with Zoloft. Some interactions can be serious, while others may simply require dose adjustments or monitoring. Always tell your doctor about all medicines you take, including herbal products and over-the-counter medicines.
Important interactions to be aware of include medicines that affect serotonin, such as other antidepressants, certain pain medicines, migraine medicines, and some supplements. The combination can raise the risk of serotonin syndrome, a potentially serious condition. Your clinician will determine if any such medicines are appropriate for you.
Other drugs that can interact with Zoloft include those that affect blood clotting or increase bleeding risk (such as NSAIDs or anticoagulants), medicines that are broken down by the same liver enzymes, and certain anti-anxiety or antipsychotic medicines. Alcohol can also interact with sertraline and may worsen drowsiness or impair judgment. Discuss all substances you use with your doctor or pharmacist to avoid problems.
If you start or stop any medicine while taking Zoloft, contact your clinician for advice. Do not start new medicines without checking first with a healthcare professional.
The safety of Zoloft during pregnancy and while breastfeeding is an important consideration. The decision to use this medicine during pregnancy depends on the balance of potential benefits to the mother and potential risks to the baby. This is a decision to be made with your doctor.
Breastfeeding may result in small amounts of sertraline passing into breast milk. If you are breastfeeding or plan to breastfeed, discuss with your clinician whether Zoloft is suitable for you and the baby. They can advise on benefits, risks, and alternatives.
In all cases, do not start or stop any treatment during pregnancy or breastfeeding without consulting a healthcare professional. If you become pregnant while taking Zoloft, contact your doctor promptly for advice on continuing or adjusting treatment.
If you have questions about pregnancy planning or fertility while on Zoloft, your doctor or pharmacist can provide guidance based on your health profile and treatment goals.
Many people notice gradual improvement in mood and anxiety after a few weeks of treatment. For others, it may take longer. If you do not feel any improvement after several weeks, speak with your clinician. Do not adjust the dose on your own.
If you miss a dose, take it as soon as you remember, unless it is near the time for your next dose. In that case, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to catch up.
Yes. Zoloft is often used as part of a broader treatment plan that may include psychotherapy (talking therapies) and lifestyle changes. Your clinician will tailor the plan to your needs and monitor your progress.
Some medicines can interact with Zoloft in ways that are important to avoid. Always tell your doctor about all medicines you take, including non-prescription drugs and supplements. Do not start new medicines without professional advice.
Zoloft can affect sleep in different people. Some may feel more rested, while others may have trouble sleeping or feel more tired. If sleep problems are troublesome, discuss timing or dosing with your clinician.
Alcohol can interact with Zoloft and may worsen side effects like drowsiness or dizziness. It is best to discuss your drinking habits with your doctor and make a plan that is safe for you.
If you experience any thoughts of harming yourself or a noticeable worsening in mood or behaviour, seek urgent medical help or contact your doctor promptly. Early support is important for safety and wellbeing.
Store the medicine in its original packaging, protected from light and moisture. Keep it out of reach of children. Do not use after the expiry date. If you have any questions about storage, ask your pharmacist.
Sertraline can be prescribed to younger people in some circumstances, but its use in children and adolescents requires careful medical supervision. The doctor will assess risks and benefits for the individual patient.
The duration of treatment varies by condition and response. Some people require short courses, while others may need longer-term treatment. Your clinician will discuss a plan with you and adjust it as needed over time.
If you notice new health problems, changes in mood, or a persistent uncomfortable reaction to the medicine, contact your doctor for advice. Do not ignore warning signs or ongoing symptoms.
Information in this page is based on standard patient information for Zoloft (sertraline) and general guidelines for antidepressants. For the most accurate guidance, refer to the official product leaflet and consult your doctor or pharmacist.
Possible reference materials include the patient information leaflets available with sertraline products in Ireland, guidance from the national health authority, and general pharmacology resources. Always follow professional medical advice for your situation.
If you have any questions about the sources of information or want to verify details, discuss with your pharmacist or doctor. They can provide the most up-to-date and locally relevant recommendations for your care.
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